| Feature | 2184insA | F508del |
|---|---|---|
| Mutation Class | Class I (frameshift) | Class II (misfolded protein) |
| Molecular Mechanism | Frameshift → truncated protein / NMD | Misfolding → trafficking defect |
| Therapeutic Options (2025) | Limited (e.g., readthrough agents) | Approved CFTR modulators |
| Prevalence | Rare (<1% CF alleles globally) | Common (~70% of CF alleles) |
| Genotype-Phenotype Variability | Moderate variability | High predictability (classic severe) |
| Research Funding Focus | Historically underfunded | Prioritized and well-funded |